Fig. 5.
Fig. 5. Effect of IL-6 on the apoptosis induced by ASO. / (A) U266 cells were electroporated with either Bcl-2, Bcl-xL, or Mcl-1 ASO or the mismatched related control. Then cells were resuspended in RPMI 1640 with 2% FCS in the presence or not of Dex (10−6 M). B-E8 was added as indicated at the concentration of 50 ng/mL. (B) Cell viability of XG-6 myeloma cells after Mcl-1 ASO delivery in the presence of 6 ng/mL IL-6.

Effect of IL-6 on the apoptosis induced by ASO.

(A) U266 cells were electroporated with either Bcl-2, Bcl-xL, or Mcl-1 ASO or the mismatched related control. Then cells were resuspended in RPMI 1640 with 2% FCS in the presence or not of Dex (10−6 M). B-E8 was added as indicated at the concentration of 50 ng/mL. (B) Cell viability of XG-6 myeloma cells after Mcl-1 ASO delivery in the presence of 6 ng/mL IL-6.

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