Clinical progression of the inflammatory disease.

Animal weight change following transplantation with TβRII^−/− (filled line) and TβRII^+/−control bone marrow (dotted line) is shown. The initial numbers of transplanted animals were 10 (TβRII^−/− donor bone marrow) and 5 (TβRII^+/− donor bone marrow). The mean weights of recipients of TβRII^−/− bone marrow and TβRII^+/− bone marrow at transplantation were 19.8 ± 2.6 g and 19.8 ± 1.0 g, respectively. Each point represents the average weight change compared to the weight at transplantation. Animal deaths occurred among TβRII^−/−bone marrow recipients from 6 to 9 weeks after transplantation. Control animals remained healthy until they were killed for histologic examination by 7 to 15 weeks after transplantation.