Factor VIII procoagulant activity in control and AOM-treated mice.

Plasmas were obtained by tail snip bleeding in control (open circles), AOM-15 (squares), AOM-30 (triangles), and AOM-50 (closed circles) groups and factor VIII was measured as described in “Materials and methods.” Each data point represents the mean value of 5 to 7 mice, except in the AOM-30 group at 48 hours (n = 3) and the AOM-50 group at 36 hours (n = 3), which had lower numbers due to death.