Effects of

bax antisense on Burkitt lymphoma viability and proliferation. Daudi (A) and RL (B) cells were cultured with either bax antisense or a mixed sense control. In addition, these cells were also cultured with either a media control or 10 μg/mL anti-CD40 (SGN-14 clone, mouse IgG1). Viability was measured by the trypan blue exclusion method. Viability was increased in the antisense-treated groups after 12 hours of CD40 stimulation, whereas the mixed sense groups showed a significant (P < .01) decrease in viability. Maximum effects were seen at 48 hours of treatment as shown above. Data are shown as the mean with SD.