Fig. 2.
Fig. 2. KGF treatment maintains normal cell cycle progression of the most immature thymocyte subsets. / Acute GVHD was induced in unirradiated B6D2F1 mice as in Figure 1. CD3, CD4, CD8 triple-negative (TN) thymocytes were analyzed 13 days after transplantation for surface expression of CD44 and CD25 and for BrdU incorporation. Upper panels: TN cellularity (total TN cell number × 105) in mice treated with KGF (▧) or with HBSS (■) was ascertained and compared with HBSS-treated B6D2F1 mice that received syngeneic transplants (▪). Lower panels: the absolute cell numbers (× 104) of BrdU+ cells among TN thymocytes were determined. Each graph represents pooled data from 2 independent experiments, with 7 mice analyzed for each group. Analysis by ANOVA; *P < .05.

KGF treatment maintains normal cell cycle progression of the most immature thymocyte subsets.

Acute GVHD was induced in unirradiated B6D2F1 mice as in Figure 1. CD3, CD4, CD8 triple-negative (TN) thymocytes were analyzed 13 days after transplantation for surface expression of CD44 and CD25 and for BrdU incorporation. Upper panels: TN cellularity (total TN cell number × 105) in mice treated with KGF (▧) or with HBSS (■) was ascertained and compared with HBSS-treated B6D2F1 mice that received syngeneic transplants (▪). Lower panels: the absolute cell numbers (× 104) of BrdU+ cells among TN thymocytes were determined. Each graph represents pooled data from 2 independent experiments, with 7 mice analyzed for each group. Analysis by ANOVA; *P < .05.

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