Fig. 4.
SU11652, SU11654, and SU11 655 induce cell cycle arrest followed by apoptosis in cell lines expressing mutant Kit.
5 × 105 (BR, C2, or P815) were cultured in with no drug or with SU11652, SU11654, or SU11655 at the indicated concentrations. Cells were collected after 24, 48, or 72 hours of culture, permeabilized with 70% EtOH, then incubated with PI. The percentage of cells undergoing cell cycling and apoptosis was assessed by flow cytometry and is represented graphically, presented as the percentage of control (untreated) cells. One of 4 representative experiments is shown.
