Platelet counts were measured in healthy SCID/NOD mice that received different treatments for the toxicity of²¹³Bi (initially at weekly and subsequently at monthly intervals).

Mice in the control group did not receive any treatment (control). Mice in another group received 250 μCi (9.25 MBq)²¹³Bi–DOTA-biotin without pretargeting and sCA (Bi-250 alone), and mice in remaining groups received 400 μg HAT-SA pretargeting for 24 hours, 100 μg sCA for 4 hours, followed by 100 μCi (3.7 MBq; Bi-100) or 250 μCi (9.25 MBq; Bi-250) or 500 μCi (18.5 MBq; Bi-500) ²¹³Bi–DOTA-biotin. Mice in the combination group received the same pretargeting, clearing steps and 250 μCi (9.25 MBq) ²¹³Bi–DOTA-biotin followed by 100 μg HAT once per week for 4 weeks.