Proliferation of autologous and allogeneic T cells in response to CD40-activated CLL cells.
(A) Proliferation of autologous and allogeneic T cells in response to weekly stimulations with CD40-activated CLL cells after 29 days of T-cell culture. Isolated T cells (2 × 106) were plated on day 0. The results represent the mean ± SD of experiments performed on 11 patients. Control T cells that were not stimulated did not survive in culture for this period. (B) Proliferation of autologous T cells in response to CD40-CLL cells compared with DCs pulsed with apoptotic bodies. Proliferation of autologous T cells in response to weekly stimulations with CD40-activated CLL cells or pulsed DCs after 29 days of T-cell culture. Isolated T cells (2 × 106) were plated on day 0. The results represent the mean ± SD of experiments performed on 11 (CD40-activated CLL cells as APCs) and 4 (pulsed DCs as APCs) patients.
