Transduction of p210 causes an STI571-dependent increase in the absolute output of erythroid cells and a decrease in the absolute output of myeloid cells.

An increased number of cells expressing erythroid markers (glycophorin A, panel A; CD36, panel B) and a decreased number of cells expressing markers of myeloid cells (CD15, panel C; CD13, panel D) were produced from the p210-transduced (GFP⁺) CB cells after culturing them for 2 weeks as described in Figure 1 and these were largely normalized in the presence of 0.25 μmol STI571. STI 571 had little or no effect on the differentiation of MIG-transduced (GFP⁺) cells. Results shown are from a representative experiment (of 4 with no STI571 and another 2 with and without STI571).