Fig. 3.
Schematic of the circularly permuted hemoglobin.
The linear polypeptide of the circularly permuted Diα globin can fold into 2 distinct 3-dimensional structures. However, only one is capable of assembling with β globins, as shown. The fact that CpHb consists of both α and β globin components suggests that the schematic shown above accurately depicts the structure of CpHb.
