Patients immunized with HER-2/neu ICD peptides, using FL as a vaccine adjuvant, can develop peptide-specific DTH responses after completing all vaccinations.

Data represent DTH responses to a combination of the ICD peptides, without adjuvant, measured as induration in mm² at 48 hours. (A) Results of the 4 patients who completed the vaccinations with FL alone as a vaccine adjuvant, each represented by their identification number. (B) Data derived from the 4 patients who received FL and GM-CSF as a vaccine adjuvant. The dotted line at 10 mm² represents a DTH value previously shown to correlate with a detectable peripheral blood T-cell response.23