Fig. 5.
Fig. 5. Effect of mAb-LE2E9 on vena cava thrombosis in FVIII−/− mice reconstituted with rhFVIII. / Inferior vena cava thrombus induction was evaluated in FVIII−/− mice following reconstitution with rhFVIII in presence or absence of mAb-LE2E9. (A) Two groups of mice (n = 9) were reconstituted with rhFVIII (7.5 IU) or with a mixture of rhFVIII (7.5 IU) and mAb-LE2E9 (10 μg) preincubated for 30 minutes in vitro. The surgical procedure for thrombus induction was started 30 minutes following reconstitution. (B) Comparison of thrombus induction in 2 groups of mice (n = 14) treated with rhFVIII (7.5 IU intravenously) followed after 15 minutes with intravenous administration of saline of mAb-LE2E9 (10 μg). The surgical procedure was initiated 30 minutes following administration of the antibody. Animals were killed after 4 hours. Thrombus scores were evaluated as in Figure 3.

Effect of mAb-LE2E9 on vena cava thrombosis in FVIII−/− mice reconstituted with rhFVIII.

Inferior vena cava thrombus induction was evaluated in FVIII−/− mice following reconstitution with rhFVIII in presence or absence of mAb-LE2E9. (A) Two groups of mice (n = 9) were reconstituted with rhFVIII (7.5 IU) or with a mixture of rhFVIII (7.5 IU) and mAb-LE2E9 (10 μg) preincubated for 30 minutes in vitro. The surgical procedure for thrombus induction was started 30 minutes following reconstitution. (B) Comparison of thrombus induction in 2 groups of mice (n = 14) treated with rhFVIII (7.5 IU intravenously) followed after 15 minutes with intravenous administration of saline of mAb-LE2E9 (10 μg). The surgical procedure was initiated 30 minutes following administration of the antibody. Animals were killed after 4 hours. Thrombus scores were evaluated as in Figure 3.

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