Pharmacokinetics and pharmacodynamics of mAb-LE2E9 in wild-type mice.

Wild-type mice were injected intravenously (A) or subcutaneously (B) with 100 μg mAb-LE2E9. Blood samples were harvested for 3 weeks, starting 5 hours after intravenous administration and 24 hours following subcutaneous administration. The concentrations of mAb-LE2E9 (open circle) are expressed as percentage of concentration in the first blood sample. FVIII activity is expressed as percentage of FVIII activity before mAb-LE2E9 injection (closed circle). Results are expressed as mean ± SD.