Cytotoxicity of CTLs against DCs pulsed with autologous tumor lysate.

(A) Cytotoxicity of CTL lines generated from patients 1 (●), 2 (○), 3 (▴), and 4 (▵) against DCs pulsed with autologous tumor lysate at different E:T ratios. (B) Comparison of the cytotoxicity of CTLs from patients 1 (▪), 2 (■), 3 (▤), and 4 (⊡) against DCs pulsed with autologous tumor lysate (Auto–Lysate-DCs), allogeneic tumor lysate from another patient (Allo–Lysate-DCs), autologous Id protein (Id-DCs), unpulsed DCs (DCs) and autologous (Auto-PCs), or allogeneic primary myeloma cells (Allo-PCs). The E:T ratio was 20:1. (C) Inhibition by antibodies against MHC class I and class II or an isotypic control IgG on the cytotoxicity of CTLs from patients 1 (▪) and 2 (■). Data are expressed as the mean ± SEM of 4 independent experiments.