Quantification of vascular lesions induced by systemic allogeneic immune responses.
SCID recipient mice were killed 2 days after transfer of 108 lymphocytes from syngeneic wt mice (1) (n = 4), or from allogeneic wt mice in the absence (2) (n = 9) or presence of recipient treatment with caspase-8 inhibitor (3) (n = 4), or after transfer of 108 lymphocytes from allogeneicgld mice (4) (n = 4), or from allogeneic lprmice (5) (n = 4); SCID recipients were killed 14 days after transfer of 2.5 × 107 lymphocytes from syngeneic (6) (n = 4) or allogeneic wt mice (7) (n = 5). Percentages are mean ± SD of 2 independent counts on tissue sections from liver, heart, kidneys, and brain of (n) different mice, as described in “Materials and methods.” *P < .007 compared to 2; °P < .007 compared to 2 and 5 (Wilcoxon test).
