Fig. 2.
![Fig. 2. Ability of TGF-β to inhibit T-cell proliferation is significantly greater in nontransduced CTLs when compared with HATGF-βRII-Δcyt–transduced CTLs. / Nontransduced CTLs, eGFP-transduced CTLs, and HATGF-βRII-Δcyt–transduced CTLs were stimulated with irradiated autologous LCLs and IL-2 ± 5 ng/mL TGF-β1. Proliferative responses were measured after 72 hours of incubation by measurement of3[H] thymidine uptake. The mean percentage of inhibition by TGF-β was measured in nontransduced CTLs (black), eGFP-transduced CTLs (white), and HATGF-βRII-Δcyt–transduced CTLs (gray). The graph represents a pooled analysis of the mean inhibition of TGF-β on3[H] thymidine uptake in the 8 CTL lines tested.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/99/9/10.1182_blood.v99.9.3179/6/h80922475002.jpeg?Expires=1726840835&Signature=eKYzvOB-FXR3X5a9mF2oxXy8h4oyhweosAgrd-aiN8vODTU4amcIrGQAOgdEcl6-K0SDsJ1Y7sEcH6HCLHqMimT3SbmSGBBakVrv4nHSGUGerlJvRFj41BjA3BihjYhAnw6VKKzNviiE2CFCbt~-t9FivdRxntJ147Xj-Qs23a-~v9FhWnGz--nD7ACo4aj-mYj0ejrq6hUuklUtwDuMOM65J07cV71wLasaY~c1l-FfiyCNZ4rhHCpYx7~ISVIl6E0XmwOpefDyleM-k0VI9kAm~WzknwTJCnZVThJ7WiLvK3DaDhTbFo-l0O-zChz4dI4F1NwNEDFVFbb3E2mTIg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Ability of TGF-β to inhibit T-cell proliferation is significantly greater in nontransduced CTLs when compared with HATGF-βRII-Δcyt–transduced CTLs.
Nontransduced CTLs, eGFP-transduced CTLs, and HATGF-βRII-Δcyt–transduced CTLs were stimulated with irradiated autologous LCLs and IL-2 ± 5 ng/mL TGF-β1. Proliferative responses were measured after 72 hours of incubation by measurement of3[H] thymidine uptake. The mean percentage of inhibition by TGF-β was measured in nontransduced CTLs (black), eGFP-transduced CTLs (white), and HATGF-βRII-Δcyt–transduced CTLs (gray). The graph represents a pooled analysis of the mean inhibition of TGF-β on3[H] thymidine uptake in the 8 CTL lines tested.
