Immunoglobulin isotype class switching of WT1 antibodies IgM to IgG in conjunction with disease progression of MDS from RA to RAEB-t.

(A) IgM and IgG WT1 antibody levels were shown by open and closed bars, respectively. Bars under the horizontal line represent that WT1 antibody was below cut-off levels. (B) WT1 antibody levels in 12 RA, 11 RAEB, and 10 RAEB-t patients were statistically analyzed.