Pathologic aspect of digestive GVHD.

(A) Duodenal biopsy with apoptotic epithelial cells (white arrow), some of them in close contact with intra-epithelial mononuclear cells (black arrows), and dense infiltrate in the lamina propria, composed mononuclear and polynuclear cells. Hematoxylin-eosin, × 250. (B) Higher magnification of damaged glandular epithelium “exploding crypt” in the lamina propria. Hematoxylin-eosin, × 400.