Summary of lineage switches observed between hematopoietic cells, placed in the context of normal hematopoietic differentiation.44 45 

(See text for details). The black lines indicate normal lineage relationships, the thick red arrows represent induced switches. (These do not necessarily imply direct transitions.) HSC indicates hematopoietic stem cell; CLP, common lymphoid progenitor; CMP, common multipotent progenitor; GMP, granulocyte/macrophage progenitor (in the text also called “myeloblasts”); MEP, megakaryocyte erythrocyte progenitor; T, T lymphocyte; B, B lymphocyte; Mac, macrophage; G, neutrophil granulocyte; Eos, eosinophil, Eb, erythroblast; E, erythrocyte; Meg, megakaryocyte; P, platelet. Mast cells, NK cells, and dendritic cells have been omitted from the scheme and placement of eosinophils is speculative. Note that most of the switches were observed with transformed cell lines in culture and that the cell type designations (both before and after the switch) may not accurately reflect the phenotype of the normal counterparts.