Inhibition of CLL cell TEM with the use of blocking mAbs to αL, α4, and α5.

After preincubation for 30 minutes at 4°C with antibody (α4, 0.5 μg/mL; α5, 2 μg/mL; and αL, 1 μg/mL), CLL-cell migration toward CLL21 was tested in the TEM model. Isotypic control antibodies had no effect on migration. The numbers on the X-axis refer to the patients listed in Table 1. The error bars represent SEMs of triplicate measurements.