Fig. 4.
Fig. 4. Activation of sDCs upon exposure to type I IFN in vivo or in vitro. / (A) Expression of CD40, CD86, or H-2Db on sDCs purified from B6 mice 4 hours after injection of PBS (filled histograms) or IFN-α/β (open histograms, solid line). (B) Expression of CD40, CD86, or H-2Db on CD11c+ sDCs purified from untreated B6 mice and placed in culture for 18 hours in medium alone (filled histograms) or in medium containing 5000 U/mL IFN-α/β (open histograms, solid line). Dashed lines show staining with isotype control antibodies.

Activation of sDCs upon exposure to type I IFN in vivo or in vitro.

(A) Expression of CD40, CD86, or H-2Db on sDCs purified from B6 mice 4 hours after injection of PBS (filled histograms) or IFN-α/β (open histograms, solid line). (B) Expression of CD40, CD86, or H-2Db on CD11c+ sDCs purified from untreated B6 mice and placed in culture for 18 hours in medium alone (filled histograms) or in medium containing 5000 U/mL IFN-α/β (open histograms, solid line). Dashed lines show staining with isotype control antibodies.

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