Addition of recombinant PAI-2 to wild-type THP-1 cells inhibits proliferation.

Normal (nontransfected) THP-1 cells were grown in the presence (▴) or absence (▪) of 1 μM recombinant PAI-2 (rPAI-2) and cell growth assessed after 5 days. As shown, addition of exogenous PAI-2 significantly inhibited THP-1 cell proliferation (P < .001; n = 3). This experiment was performed in triplicate on 3 separate occasions.