Fig. 4.
Fig. 4. THP-1 cells stably expressing wild-type PAI-2 display a loss of cell-cell adhesion. / (A) Representative images of nontransfected THP-1 cells (i), cells transfected with pCI-neo (ii), pCI–PAI-2wt (clone c) (iii), or pCI–PAI-2Ala380 (clone g) (iv). Phase contrast photomicrographs (magnification × 200). Cells transfected with wild-type PAI-2 do not grow as clumps but instead grow as individual cells in suspension. (B) Quantitation of results presented in panel A. Percentage of single cells compared with total cell number was determined in 5 separate fields.

THP-1 cells stably expressing wild-type PAI-2 display a loss of cell-cell adhesion.

(A) Representative images of nontransfected THP-1 cells (i), cells transfected with pCI-neo (ii), pCI–PAI-2wt (clone c) (iii), or pCI–PAI-2Ala380 (clone g) (iv). Phase contrast photomicrographs (magnification × 200). Cells transfected with wild-type PAI-2 do not grow as clumps but instead grow as individual cells in suspension. (B) Quantitation of results presented in panel A. Percentage of single cells compared with total cell number was determined in 5 separate fields.

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