IDCs from lymph nodes of monkeys with AIDS have reduced expression of CD40.

Lymph node cell suspensions from normal, healthy animals (N, n = 5) and monkeys with acute SIV infection (A, n = 7) or AIDS (n = 5) were labeled and gated on expression of CD83 and lack of CD20 to identify IDCs, and the mean fluorescence intensity (MFI) of a panel of cell surface markers was determined. CD40 expression on IDCs from monkeys with AIDS is reduced as compared to normal animals (P < .03). Each circle represents a different animal, and horizontal bars represent the mean.