Percentage of glomeruli with fibrin deposition (%GFD) in AT+/+ and AT+/− mice.

(A) The %GFD of AT+/+ mice and AT+/− mice after LPS challenge. LPS was intraperitoneally injected into mice as described in “Materials and methods.” After 4 hours, kidney specimens were subjected to immunohistochemical analysis as described in the legend to Figure 2. The %GFD was significantly higher inAT+/− mice than in AT+/+ mice (n = 12,P < .01). (B) The %GFD of AT+/+ mice andAT+/− mice after exposure to restraint stress. Mice were placed in 50-mL tubes for 20 hours with appropriate water and air supply. The %GFD was significantly higher in AT+/− mice than in AT+/+ mice (n = 8; P < .05). Values are means ± SD.