Representative karyotypes illustrating the various chromosomal rearrangements identified in SKY analysis.

(A) SKY karyotype of case 2612 with primary effusion lymphoma showing several multiple complex and cryptic translocations, notably, t(3;14)(q27;q32) and der(14)t(1;14)(?;q32). The display colors are shown on the left and the classification colors on the right. (B) Confirmation of t(3;14)(q27;q32) by FISH using PAC probe 120H10 (14q32). The lack of green signal on chromosome 1 confirms the nonreciprocal nature of der(14)t(1;14). (C) The same metaphase was washed and rehybridized with whole chromosome painting probe for chromosomes 1 (green) and 14 (red). Presence of green signal on chromosome 14 confirms der(14)t(1;14)(?;q32). (D) Partial karyotypes (from left to right) showing the 3 new and 2 potentially new recurring translocations. Inverted DAPI band image of the involved chromosome is shown on the left and the classification color on the right.