Immunization with P815–IL-17 cells partly protects against challenge with wild-type P815 cells.

DBA/2 mice were immunized with live IL-17–transfected P815 cells (5 × 10⁴). Eighteen days later, tumor-free mice were challenged with either wild-type P815 cells (5 × 10⁵; A) or KLN 205 melanoma cells (10⁶; B). Ten to 12 mice per group were used for each experiment. (C) DBA/2 mice were either not immunized or immunized with 5 × 10⁴ IL-17–transfected P815 A-E− cells. Fifteen days later, tumor-free mice were challenged with wild-type P815 A-E− cells (5 × 10⁵).