Correction of liver pathology in TNS9-treated chimeras.

(A) Upper left: livers from Hbb^+/+ control mice showed no evidence of EMH. Upper right: livers from Hbb^th3/+ control mice showed a significant amount of EMH as evidenced by the presence of erythroid precursors in the sinusoids. Lower left: livers from Hbb^th3/+ mice that received transplants of eGFP-transduced Hbb^th3/+ bone marrow showed evidence of EMH. Lower right: similar to the normal control livers, the Hbb^th3/+ mice that received transplants of TNS9-treated Hbb^th3/+ bone marrow showed no evidence of EMH. Original magnification × 88. (B) Upper left: no iron was identified in the livers of Hbb^+/+control mice. Upper right: a moderate amount of iron was seen in livers from Hbb^th3/+ control mice. Lower left: a large amount of iron was seen in the livers of Hbb^th3/+ mice that received transplants of eGFP-treated Hbb^th3/+ bone marrow. Lower right: iron was only rarely identified in the Hbb^th3/+mouse that received a transplant of TNS9-treated Hbb^th3/+bone marrow cells. Original magnification × 88.