Inhibition of FLIP expression with antisense oligonucleotides sensitizes TRAIL-resistant MM cells to TRAIL.

Cell death of highly TRAIL-resistant IM-9 cells transfected with either FLIP antisense (ASO) or control (CO) oligonucleotides, and then treated with or without TRAIL (200 ng/mL) for 18 hours. FLIP and tubulin protein levels are shown for comparison.