STI571 modulates the expression of ICAM-1 by UT-7/9 cells and decreases the susceptibility of UT-7/9 targets to dNK cytolysis.

(A) UT-7 and UT-7/9 cells were treated for 48 hours by STI571 (thin lines) and analyzed by cytometry for expression of HLA class I, ICAM-1, and LFA-1. Bold lines indicate untreated cells. (B) K562, UT-7/G6, and UT-7/9 cells were treated by STI571 and used as targets in a cytotoxic assay with dNK cells as effectors. One representative experiment of 4 is shown.