Kinetics of the expression of cell cycle regulatory proteins and dephosphorylation of pRB, associated with ATRA-induced differentiation.

(A) The temporal changes in protein expression of the indicated cell cycle regulators based on the quantification of Western blot data from Figures 2B and 3B; cyclin A (▴), cyclin B (♦), cyclin E (●), p27 (*). (B) Kinetics of pRb dephosphorylation at specific sites based on the quantification of Western blot data from Figure 4B; Ser780 (♦), Ser795 (▴), Ser807/811 (●). Quantified data are displayed with the peak value for each series arbitrarily set to 100. For cycling cells the actual percentage of cells in the S+G₂/M phases of the cell cycle is shown.