Fig. 4.
Fig. 4. Alloantigen-specific cytotoxic T lymphocytes can be generated in stable mixed chimera containing cells of 3 different origins. / More than 100 days after transplantation, cells were activated with irradiated (20 Gy) spleen cells from C3H/HeJ mice in a 112-hour mixed lymphocyte reaction in 96-well round-bottom culture plates. The cells were tested in situ for lysis of 51Cr-labeled 2-day Con A blast cells from C3H/HeJ. The values represent the mean + SE of 3 values in each group. Not significant: C57BL/6+SJL/J→BALB/c versus normal mice or single-donor recipients at the effector-target ratio of 50:1.

Alloantigen-specific cytotoxic T lymphocytes can be generated in stable mixed chimera containing cells of 3 different origins.

More than 100 days after transplantation, cells were activated with irradiated (20 Gy) spleen cells from C3H/HeJ mice in a 112-hour mixed lymphocyte reaction in 96-well round-bottom culture plates. The cells were tested in situ for lysis of 51Cr-labeled 2-day Con A blast cells from C3H/HeJ. The values represent the mean + SE of 3 values in each group. Not significant: C57BL/6+SJL/J→BALB/c versus normal mice or single-donor recipients at the effector-target ratio of 50:1.

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