Hematologic parameters are partially normalized in mice with partial RBC chimerism.

(A) Hemoglobin concentration (g/dL, as determined by automated complete blood count analysis) versus percent peripheral RBC engraftment. (B) Hematocrit (percentage, as determined by automated complete blood count analysis) versus percent peripheral RBC engraftment. (C) Reticulocyte count (percent thiazole⁺, Ter-119⁺ cells determined by flow cytometry) versus percent peripheral RBC engraftment. (D) Spleen size (as percentage of total body weight) versus percent peripheral RBC engraftment. For all panels, age-matched, unengrafted sickle mice were used for 0% engraftment controls (n = 4), and engrafted animals (n = 4) were used as 100% engrafted controls. Each of the other points represents individual mice with varying levels of peripheral RBC engraftment.