Quantitation of CD8⁺IFN-γ⁺cells after sensitization with autologous or allogeneic EBV BLCL.

An EBV-specific and an alloreactive T-cell line of the same donor were generated, and the IFN-γ–producing CD8⁺ T cells in response to autologous or allogeneic BLCL were determined on day 12 of culture. Bars on the left illustrate the responses of T cells sensitized with autologous BLCL, and bars on the right illustrate the responses of T cells sensitized with allogeneic BLCL. Both T-cell lines predominantly produced IFN-γ specifically in response to their sensitizing BLCL.