Pedigree of Donor A's family showing members positive for the Gln93-encoding allele.

Genomic DNA samples were obtained from members of Donor A's immediate family and were genotyped for the presence of the Gln93 encoding β3 integrin allele. A complete HPA genotype was also obtained by PCR-SSP (data not shown). The mutant β3Gln93 integrin allele was found in the mother (Donor C) and in the proband. Black symbols represent β3Gln93-positive members, open symbols represent β3Gln93-negative members, and the arrow indicates the proband (Donor A). Samples were not available from members represented by broken symbols.