Profound decrease of switched memory B cells in CVID patients of subgroups A and B.

PBMCs were stained for the expression of CD19, CD27, IgM, and IgD, as shown in Figure 1. CVID patients are assigned to groups A-C according to the classification by Bryant et al9 and are compared with healthy controls (HD). Rhombus symbols represent the percentage of switched memory B cells (CD27⁺IgM⁻IgD⁻) for each patient or healthy donor. Statistical analysis was performed by the Student t test, and P values are given.