Fig. 5.
Growth arrest of K562 cell lines induced by expression of wild-type Gab2, but not by SHP2-binding defective Gab2.
K562-derived cell lines pSTAR-2, Gab2WT-3, Gab2WT-6, Gab2WT-7, Gab2Tyr604Phe-5, or Gab2Tyr604Phe-11 were plated at a cell density of 1 × 105/mL and treated with or without dox (1 μg/mL). Total cell numbers of each sample were determined every 24 hours for 120 hours. The data represent means and SDs of 2 duplicate experiments.
