D15 versus D29 residual disease levels.

Scatterplot of 66 patients examined both at D15 and at D29 after the start of treatment. Open symbols denote B-lineage leukemia and filled symbols denote T-lineage leukemia. ■ indicates that both D15 and D29 MRD levels are above the limit of detection. ▿ indicates that D15 MRD is detectable, but D29 is below the limit of detection and the level is set to the reciprocal value of the number of cells examined. ⋄ indicates that D29 MRD is detectable, but D15 level is below the limit of detection and the level is set to the reciprocal level of the number of cells examined. ▵ indicates that D15 and D29 levels are both below the limit of detection and the MRD levels are set to the reciprocal values of the number of cells examined. Rank correlations: all patients, n = 66, r_S = 0.70, P < .0001; T-lineage ALL, n = 9, r_S = 0.90, P = .002; B-lineage ALL, n = 57, r_S = 0.61,P < .0001.