Breakpoints of the

HOXA11 and HOXA13 genes.(A) Southern blot analysis of leukemic cell samples derived from 2 patients with the t(7;11)(p15;p15) translocation (Y and S). (Left panel) Rearrangement of HOXA11 (arrows) was detected byBamHI and EcoRI digestion in patient Y. (right panel) Rearrangement of HOXA13 (arrow) was detected byEcoRI digestion in patient S. (B) Chromosome breaks on 7p15 in patient Y and S. (Top panel) Overview of the 5′ half of theHOXA cluster on chromosome 7. (bottom panel) Mapping of the breakpoints (arrows) within HOXA11 and HOX13 in patients Y and S, respectively. Locations of the probes used for Southern blot analysis are also shown as open (HOXA11) and hatched (HOXA13) boxes. R indicates EcoRI; B,BamHI.