Fig. 1.
NUP98-HOXA11 and NUP98-HOXA13 fusions in AML and MDS.
(A) Southern blot analysis of the leukemic cell sample derived from t(7;11)(p15;p15) CML (patient Y). Normal human DNA (N) was used as a control. Rearranged bands in a patient with the t(7;11) translocation were detected by BamHI and EcoRI digestion (arrows). (B) Hemi-degenerate RT-PCR.NUP98-HOXA fusion transcripts were detected as products of different molecular sizes. M indicates 100-bp ladder molecular weight marker; J, patient J with known NUP98-HOXA9fusion5; S, patient S; Y, patient Y; ddw, H2O. (C) Nucleotide and deduced amino acid sequences ofNUP98-HOXA11 and NUP98-HOXA13 fusions in Y and S.
