Reduction of alveolar macrophage population by CP.

Mice were injected subcutaneously with CP as described in Figure 1B. At various times after the first CP, mice were killed and alveolar macrophages were obtained from bronchoalveolar lavage fluids. The number of alveolar macrophages was determined on cytospins. Results are expressed as mean ± SEM from 20 (control), 16 (day 4), 14 (day 10), 5 (day 14), 8 (day 18), 7 (day 25), and 6 (day 35) mice. When compared with the control, the differences at various times are all statistically significant.