Fig. 7.
![Fig. 7. Effect of NK cell depletion on IL-18/IL-2 lethality. / (A) Effect of antiasialo-GM1 Ab. SCID mice (n = 5) were pretreated with 1 mg (100 μL) antiasialo-GM1 [asialo] Ab or control normal rabbit serum (NRS) on days 0 and 7 to deplete the NK-cell population. The NK-cell–depleted SCID mice were then treated daily with control PBS or IL-18 (1 μg) plus IL-2 (100 000 IU) once a day for 10 days. (B) Effect of anti-NK1.1 mAb. B6 mice (n = 5) were pretreated with 0.5 mg anti-NK1.1 mAb, CD4 mAb, CD8 mAb, or control antibody on days 0 and 7. Mice were then treated daily with IL-18 (1 μg) plus IL-2 (100 000 IU) once a day for 10 days.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/99/4/10.1182_blood.v99.4.1289/6/h80422124007.jpeg?Expires=1722703744&Signature=mOJllF3~7UNRLaCZTxYtpvzDPEAoD5VCJnRxoeGiyYhfFXl2aCFEwzPG8srgXUr-tPIwjKufiwlqlfmvWH~RoMZG~SSFmUvdxekZO28WhDxP89QiNtvxdgvJG~suyiX9-~Ic8jXZliL7jtk2czpHZ7vLE0dSDH9z5O3SEmrP3SEtDOOPkVKxSuc4uoBLh4QuwRhnuc-JnY9JVnXOJLeLerSU5iFOm2hcC9JN~af9npv3i05GMc7bChCV1oxIEjTVss~iw2Q~yoaidp7W-461jTF9q8WYsVJ9nK~~jZqjxc4jDOZhCa-vgc9NETyZNZEsOXp2smGnOqoftDY7hRpC2w__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Effect of NK cell depletion on IL-18/IL-2 lethality.
(A) Effect of antiasialo-GM1 Ab. SCID mice (n = 5) were pretreated with 1 mg (100 μL) antiasialo-GM1 [asialo] Ab or control normal rabbit serum (NRS) on days 0 and 7 to deplete the NK-cell population. The NK-cell–depleted SCID mice were then treated daily with control PBS or IL-18 (1 μg) plus IL-2 (100 000 IU) once a day for 10 days. (B) Effect of anti-NK1.1 mAb. B6 mice (n = 5) were pretreated with 0.5 mg anti-NK1.1 mAb, CD4 mAb, CD8 mAb, or control antibody on days 0 and 7. Mice were then treated daily with IL-18 (1 μg) plus IL-2 (100 000 IU) once a day for 10 days.
