Effects of blocking RBC adhesion markers on adhesion.

Washed RBCs from patients with SCD were pretreated with either anti-CD36 alone, annexin V alone, or in combination to cloak cell surface CD36 and PS and then assessed simultaneously for their adhesion potential and surface adhesion marker levels as described. Mean adhesion ratio for untreated control sickle RBCs in these experiments was 7.03 ± 1.28. Values presented are the mean ± SD from 6 patients.