The ultrastructure of RPE and choroidal melanosomes of double mutant mice are severely altered.

Adult eye tissues from (A) control or wild-type C57Bl/6J (+/+), (B) pearl (pe/pe), (C) pale ear (ep/ep), and (D) mice doubly mutant for pale ear and pearl genes (ep/ep, pe/pe) were analyzed by electron microscopy. The interface between the RPE and choroid (CH) regions is indicated by the hyphenated partial line. The RPE is above the line and the CH is below.