Differentiation response of APL cells.

APL cells from case 6 (A) and from AP-1060 cells derived from case 1 (B) were cultured for the indicated time in the absence of agents (○), in 1 μM RA (▴), in 1 mM NaB (⋄), or in 1 μM RA + 1 mM NaB (●). The percentage of terminally differentiated APL cells was measured in case 6 by the expression of CD11b surface antigen detected by flow cytometry (A) or in AP-1060 cells by the nitroblue tetrazolium dye reduction test (B).