Transcriptional activity of wild-type and mutant PML-RARα fusion proteins in variable RA concentrations with or without NaB or TSA.

The DR5-tk-luc reporter was cotransfected with L-form PML-RARα (left panel) or S-form PML-RARα (right panel) in the absence of HDI (A), in the presence of 5 mM NaB (B) or 150 nM TSA (C). pSG5 represents the vector alone. Luciferase activity with different concentrations of RA is shown after normalization with β-gal activity with the corresponding, calculated fold-induction value indicated below.