Position of naturally occurring missense mutations in 3 zones of the ligand-binding domain of the RARα region.

Panel A shows the RARα region of PML-RARα, and Panel B 3 zones of clustered mutations in the homologous TRβ defined in extensive studies of RTHS.27,28 Asterisks indicate the positions of the 5 missense mutations found in this report. Roman numerals I to III designate the 3 clustered mutation zones. The numbers below the zones indicate the number of mutations identified in each of the 3 zones, as follows: (A) unique (numerator) and total (denominator) naturally occurring PML-RARα mutants and (B) the number of unique mutations in TRβ in the RTHS in the cited reviews.28 29