The activation of inflammation-elicited peritoneal macrophages is fibrinogen dependent.

Fibrinogen-deficient (−/−, ■) and littermate control (+/−, ▪) mice were compared, using the assays described in Figure 1. The data represent the averages and standard deviations of 5 animals per group. TG-induced recruitment of inflammatory macrophages was not significantly impaired in fibrinogen-deficient mice, but macrophage activation was significantly diminished in the absence of fibrinogen (Th1/Ova, P < .002; LPS, P < .002). This experiment was repeated 3 times.