The activation of inflammation-elicited peritoneal macrophages is not PAR-1 dependent.

PAR-1–deficient (−/−, ■) and littermate control (+/−, ▪) mice were compared, using the assays described in Figure 1. The data represent the averages and standard deviations of 5 animals per group. Neither TG-induced macrophage recruitment nor macrophage activation were significantly impaired in PAR-1–deficient mice.