Fig. 5.
Fig. 5. Normal and mutant ADA C-terminal amino acids and final splice acceptor sites. / (A) C-termini of wild-type (WT) and MutA proteins (single-letter amino acid code). (B) IVS 11 splice acceptor sites. The consensus splice site58 is shown schematically to locate the conserved AG dinucleotide, the polypyrimidine tract Pyn, and the branchpoint A. In the wild-type (WT), MutA, and MutAΔ11 transcripts (below) nt removed by splicing are in lower case; nt retained in exon 12 are in capitals. The positions of nt −1 are indicated; arrows indicate g.31701 (mutated in MutA and MutAΔ11), and possible branchpoint at g.31686. The 13-nt insertion at the exon 11/12 junction due to MutA is in italics. Dashes indicate the 11-nt deletion in MutAΔ11.

Normal and mutant ADA C-terminal amino acids and final splice acceptor sites.

(A) C-termini of wild-type (WT) and MutA proteins (single-letter amino acid code). (B) IVS 11 splice acceptor sites. The consensus splice site58 is shown schematically to locate the conserved AG dinucleotide, the polypyrimidine tract Pyn, and the branchpoint A. In the wild-type (WT), MutA, and MutAΔ11 transcripts (below) nt removed by splicing are in lower case; nt retained in exon 12 are in capitals. The positions of nt −1 are indicated; arrows indicate g.31701 (mutated in MutA and MutAΔ11), and possible branchpoint at g.31686. The 13-nt insertion at the exon 11/12 junction due to MutA is in italics. Dashes indicate the 11-nt deletion in MutAΔ11.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal